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Can ResponseAdaptive Randomization Increase Participation in Acute Stroke Trials? Jason S. Tehran, MPH; William J. Member, MD, Downloaded from http://stroke.ahajournals.org/ by guest on February 15,

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What is can response-adaptive randomization increase?

Response-adaptive randomization can increase the probability of assigning more participants to the more effective treatment arm in a clinical trial.

Who is required to file can response-adaptive randomization increase?

Researchers conducting clinical trials or studies with response-adaptive randomization are required to file for approval.

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The application for response-adaptive randomization increase must include detailed methodology, statistical analysis plan, and ethical considerations.

What is the purpose of can response-adaptive randomization increase?

The purpose of response-adaptive randomization increase is to optimize the allocation of participants to treatment arms based on accumulating data.

What information must be reported on can response-adaptive randomization increase?

The application must report the rationale for using response-adaptive randomization, details of the adaptive design, and mechanisms to control for bias.

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