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Hello everybody welcome to Jeff the pharmacist it is an honor to have you here so today were talking about, and I just want to say I'm sorry I haven't been here in a little while I was on vacation with my husband we were in Taiwan and Japan and with his parents, so I'm just hanging out with the in-laws everything was in Chinese, so I had a lot of time in here, so I want to thank you guys for tuning in today were talking about, so I want to talk about how the drugs take in some side effects with the drug how the drug works I want to end the video with how effective it is and in diabetes drugs we look at a 1 C so is a drug that works specifically on your kidneys so if you're on dialysis that wouldn't be a drug for you if you have poor kidney function it wouldn't be a drug for you its it requires decent kidney function in order for the drug to work and there's actually a parameter on how much of the drug you would get based on Kenny function so some people who have mildly reduced kidney function could still take the drug is a little taxing on the kidneys in there are some people who do have issues with kidney function on the drug and that makes sense because it does work on the kidneys the way it works is it inhibits something called sodium-glucose cotransport ER so what that does be if you think of the kidneys its like a big filter so your heart pumps the kidney your heart pumps blood throughout your body, and it pumps blood through your kidneys and your kidneys kind of filter all this crap down that comes out of your blood into urine, so it takes poison and stuff out of it that's why people need the kidneys if they don't have it therell be too much their blood will become toxic so what the sodium glues those co-transporter does is basically would keep glucose in your blood because you kind of need glucose is something that is supposed to be kind of scarce in the environment it's not in 2019 in America what it does is it allows you to basically pee on glucose, so you know if your urine basically becomes Kool-Aid or lemonade and that helps to reduce the amount of sugar in your blood because you're peeing it out another thing is it can also increase the volume that you're peeing out and that can actually be caused one of the side effects which is hypokalemia or low blood volume and low blood volume can translate into lower blood pressure and lower blood pressure can cause people to get dizzy and fall, so that's one of the side effects is false because if your blood pressure is lower you stand up you start to feel dizzy, and you know even as a kid this would happen to me where I'd be sitting on the couch for like nine hours and I get up real quick, and then I would start to almost like blackout, so that's something that could happen with since it is a drug that works on the kidneys it can impair some of your kidney function in the package in insert they wrote about how people on the higher dose of in milk on it had four percent of them had some event...
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