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SUMMER 2018Why trials sometimes fail:INSIDE THIS ISSUE:The challenging road to Alzheimer\'s preventionChallenging AD1Dementia Care2A Family Affair316th Brain Health Forum 4 Preventing Dementia4Alzheimers
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01
Start by identifying the objective of the trial and what you hope to achieve.
02
Develop a clear and well-defined hypothesis that you want to test.
03
Plan and design the trial carefully, considering important factors such as sample size, controls, and randomization.
04
Ensure that your trial is ethically sound and follows all applicable regulations and guidelines.
05
Implement the trial according to the planned design, collecting and recording all necessary data.
06
Analyze the data collected during the trial, using appropriate statistical methods.
07
Interpret the results of the trial, considering any limitations or biases that may be present.
08
Communicate the findings of the trial, both internally and externally, and consider the implications for future research or practice.
09
Reflect on the reasons why the trial may have failed and identify any lessons learned for future trials.
10
Make any necessary adjustments or improvements to the trial design for future attempts.

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Trials sometimes fail due to various reasons such as inadequate sample size, flawed study design, or unexpected outcomes.
Researchers, investigators, and sponsors of clinical trials are required to report the reasons for trial failures.
The reasons for trial failures can be documented by analyzing the trial data, conducting root cause analysis, and consulting with relevant stakeholders.
The purpose of reporting trial failures is to improve future study designs, identify areas for improvement in the clinical trial process, and ensure transparency in research.
Information such as the reasons for trial discontinuation, study design flaws, unexpected adverse events, and any protocol deviations must be reported on trial failures.
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