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SEC Form 4UNITED STATES SECURITIES AND EXCHANGE COMMISSIONER 4Washington, D.C. 20549Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).STATEMENT

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Karyopharm Therapeutics Inc. is a clinical-stage pharmaceutical company focused on the development of therapies for cancer and other serious diseases, utilizing its proprietary drug discovery platform.

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The purpose of Karyopharm Therapeutics Inc. is to develop innovative drugs targeting serious diseases, with an emphasis on cancer treatment, to improve patient outcomes.

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