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This document outlines the updated protocol for the National Wilms Tumor Study's Late Effects of Treatment in Wilms Tumor Survivors and Offspring, detailing specific revisions made to the title page,
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How to fill out National Wilms Tumor Study Late Effects of Treatment in Wilms Tumor Survivors and Offspring

01
Obtain a copy of the National Wilms Tumor Study Late Effects of Treatment in Wilms Tumor Survivors and Offspring questionnaire.
02
Carefully read the instructions provided with the questionnaire.
03
Gather relevant medical history, treatment details, and follow-up records for both the Wilms tumor survivor and their offspring.
04
Begin filling out the questionnaire by providing the survivor's personal information, including name, date of birth, and treatment history.
05
Answer all questions regarding late effects of treatment, including both physical and psychological health impacts.
06
Ensure that you provide accurate information regarding the offspring's health, developmental milestones, and any potential hereditary concerns.
07
Review all completed sections for accuracy before submitting the questionnaire.
08
Submit the filled-out questionnaire as per the provided instructions, either online or via mail.

Who needs National Wilms Tumor Study Late Effects of Treatment in Wilms Tumor Survivors and Offspring?

01
Wilms tumor survivors who have undergone treatment and are experiencing late effects.
02
Parents or guardians of Wilms tumor survivors who want to understand potential risks for their offspring.
03
Healthcare providers looking to assess the long-term effects of Wilms tumor treatment on their patients.
04
Researchers studying the late repercussions of Wilms tumor and its treatments.
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People Also Ask about

Wilms tumour that comes back after treatment is called relapsed disease. It can be more difficult to control relapsed or refractory Wilms tumour but there are treatments available. Relapsed Wilms tumour are rare. If it does come back, it is most likely to happen in the first 2 years after treatment.
Follow-up exams and tests after Wilms tumor treatment This includes physical exams and imaging tests (like chest x-rays, ultrasounds, and CT scans). These exams and tests will look for the growth or return of the tumor, or any problems related to treatment.
In high-income countries, the overall survival of children with Wilms tumors (WT) is ~90%. However, overall, 15% of patients experience tumor recurrence.
Wilms tumour classically follows the “rule of 10's”: up to 10% may have unfavourable histology, 10% are bilateral, 10% have vascular invasion, 10% have calcifications on CT and 10% have pulmonary metastases at presentation [19].
What cancer treatments cause late effects? TreatmentLate effects Surgery Lymphedema Hormone therapy Blood clots Hot flashes Increased risk of other cancers Menopausal symptoms Osteoporosis Sexual side effects Immunotherapy Joint or muscle problems Targeted therapy Blood clots Heart and vascular problems2 more rows
Possible Complications High blood pressure and kidney damage may occur as the result of the tumor or its treatment. Removal of WT from both kidneys may affect kidney function. Other possible complications of the long-term treatment of WT may include: Heart failure.
These late effects include problems with heart muscle function, such as left ventricular dysfunction or cardiomyopathy. Chemotherapy for Wilms tumour can also lead to abnormal heart rhythms (arrhythmias).
Stage 4. The cancer has spread outside of the abdomen to other parts of the body (called distant metastasis), such as to lymph nodes outside the abdomen, the lungs, the liver or bone. About 10% of Wilms tumours are stage 4. A child with stage 4 Wilms tumour may still have a low local stage.

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The National Wilms Tumor Study Late Effects of Treatment in Wilms Tumor Survivors and Offspring is a research initiative aimed at understanding the long-term effects of treatment for Wilms tumor on survivors and their offspring, including health outcomes and psychosocial impacts.
Wilms tumor survivors and their parents or guardians are typically required to file the study forms to help collect data regarding their health and any late effects of treatment.
To fill out the National Wilms Tumor Study forms, participants should gather relevant medical history, treatment details, and current health status, and then complete the provided questionnaires according to the instructions given for each section.
The purpose of the study is to identify and document the long-term physical and psychological effects of Wilms tumor treatments, helping to improve care and inform future treatment protocols.
Participants must report information related to their medical history, types of treatments received, current health conditions, psychological well-being, and any health issues experienced by their offspring.
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