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NIH Clinical Center Grand Rounds, April 13, 2022, ON NIH VIDEOCAM Julius Strauss, MD Combination Immunotherapy in HPV Related Cancers Associate Research Physician, Laboratory of Tumor Immunology and
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01
Identify the specific immune correlates being studied in the clinical trial.
02
Collect blood samples from the participants at specific time points during the trial.
03
Use validated assays to measure the levels of immune cells, cytokines, and other immune markers in the blood samples.
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Analyze the data to determine correlations between the immune response and clinical outcomes.
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Consider factors such as age, sex, and comorbidities when interpreting the results.
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Report findings in a clear and concise manner in the final study report.

Who needs immune correlates of clinical?

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Researchers conducting clinical trials to evaluate the effectiveness of novel immunotherapies.
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Drug developers seeking to understand the mechanisms of action of their compounds.
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Regulatory agencies evaluating the safety and efficacy of new treatments.
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Clinicians looking to personalize treatment plans based on individual patients' immune profiles.
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Immune correlates of clinical refer to the measures or markers of immune response that are used to predict the outcome of vaccination or disease.
Researchers, clinicians, and pharmaceutical companies are typically required to file immune correlates of clinical for vaccine development or clinical trials.
Immune correlates of clinical are typically filled out by providing data on immune response markers, participant information, study protocol, and results of the clinical trial.
The purpose of immune correlates of clinical is to assess the effectiveness of vaccines, predict vaccine efficacy, understand immune responses to diseases, and inform vaccine development.
Information on immune response markers, study participants, study design, results, and conclusions must be reported on immune correlates of clinical.
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