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This document presents GeneSigDB, a manually curated database of gene expression signatures focusing on cancer and stem cells, constructed from numerous publications to facilitate standardized access
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How to fill out GeneSigDB—A Curated Database of Gene Expression Signatures
01
Visit the GeneSigDB website.
02
Create an account or log in if you already have one.
03
Select the option to submit a new gene expression signature.
04
Fill out the required fields, including study details, gene list, and relevant experimental conditions.
05
Provide any links to published articles or external datasets if available.
06
Review your entry for accuracy and completeness.
07
Submit the form and wait for confirmation of submission.
Who needs GeneSigDB—A Curated Database of Gene Expression Signatures?
01
Researchers studying gene expression patterns in various diseases.
02
Clinicians looking for gene expression signatures for personalized medicine.
03
Bioinformaticians analyzing large datasets involving gene expression.
04
Students and educators in the field of genomics and molecular biology.
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People Also Ask about
What is meant by gene expression signature?
By definition, a gene expression signature is a particular group of genes correlating genetic alterations with specific clinical variables, such as diagnosis or prognosis [1].
How to display gene expression data?
A common method of visualising gene expression data is to display it as a heatmap (Figure 17). The heatmap may also be combined with clustering methods which group genes and/or samples together based on the similarity of their gene expression pattern.
What is a gene expression database?
The Gene Expression Database (GXD) is a community resource for gene expression information from the laboratory mouse. GXD stores and integrates different types of expression data and makes these data freely available in formats appropriate for comprehensive analysis.
What is the gene database and what is it used for?
The NCBI Gene database has information on gene sequences, gene alleles and mutations, genomes, amino acid sequences for proteins, and much more genetic data on humans, as well as many other animal species. You can explore many resources on the NCBI Gene database.
What are the 4 levels of gene expression?
Regulation of gene expression can happen at any of the stages as DNA is transcribed into mRNA and mRNA is translated into protein. For convenience, regulation is divided into five levels: epigenetic, transcriptional, post-transcriptional, translational, and post-translational (Figure 17.6).
What are gene expression databases?
About the Gene Expression Database (GXD) The Gene Expression Database (GXD) is a community resource for gene expression information from the laboratory mouse. GXD stores and integrates different types of expression data and makes these data freely available in formats appropriate for comprehensive analysis.
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What is GeneSigDB—A Curated Database of Gene Expression Signatures?
GeneSigDB is a curated database that contains information on gene expression signatures associated with various biological processes, diseases, and treatments. It serves as a resource for researchers to explore the relationships between gene expression and phenotypic outcomes.
Who is required to file GeneSigDB—A Curated Database of Gene Expression Signatures?
Researchers and scientists who generate gene expression data and wish to share their findings with the scientific community are encouraged to file their gene expression signatures in GeneSigDB.
How to fill out GeneSigDB—A Curated Database of Gene Expression Signatures?
To fill out GeneSigDB, users must provide detailed information about their gene expression study, including the experimental design, data analysis methods, and any relevant metadata about the samples used.
What is the purpose of GeneSigDB—A Curated Database of Gene Expression Signatures?
The purpose of GeneSigDB is to facilitate the sharing and discovery of gene expression signatures, thus accelerating research in genomics and personalized medicine by providing a comprehensive resource for understanding gene expression patterns.
What information must be reported on GeneSigDB—A Curated Database of Gene Expression Signatures?
Information that must be reported includes gene identifiers, expression data, experimental conditions, clinical outcomes, and any other context-specific details that would help interpret the gene expression signature.
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