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This clinical trial protocol describes a study comparing the effects of short-term androgen deprivation therapy and radiotherapy on prostate cancer patients with a rising PSA after radical prostatectomy,
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How to fill out RTOG 0534 Protocol

01
Obtain a copy of the RTOG 0534 Protocol document.
02
Read the entire protocol to understand the eligibility criteria and objectives.
03
Prepare the necessary patient information and relevant medical history.
04
Identify the inclusion and exclusion criteria for patient participation.
05
Collect and organize all required baseline assessments as specified in the protocol.
06
Complete the case report forms (CRFs) provided in the protocol.
07
Ensure that consent forms are signed by the patient and guardians, if applicable.
08
Submit the filled protocol documentation to the ethical review board if required.
09
Monitor and record patient responses and adverse events during the protocol implementation.
10
Follow up with the necessary documentation for trial outcomes and findings.

Who needs RTOG 0534 Protocol?

01
Patients diagnosed with the specific conditions outlined in the RTOG 0534 Protocol.
02
Clinical researchers and healthcare professionals conducting related studies.
03
Healthcare institutions wishing to participate in the RTOG 0534 trial.
04
Regulatory bodies monitoring clinical trial adherence to protocols.
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It is highly effective in achieving local control of tumor growth. Most studies report local control rate of over 80%. Because the entire cerebrum is radiated, WBRT “sterilizes” regions of the brain that are not affected by the macroscopic tumor.
Based on our own institutional practice, it was observed that despite the standard RTOG 90-05 guideline doses of 15, 18 and 24Gy, radiosurgeons at our institution would often prescribe modified doses in between these numbers i.e. 16, 20 and 22Gy taking into account lesion size and number to be treated (as an estimate
The Radiation Therapy Oncology Group (RTOG) scoring criteria for radiation-induced oral mucositis. (a) Grade I: Erythema; (b) Grade II: Patchy reaction (<1.5 cm, non-contiguous); (c) Grade III: Confluent mucositis (>1.5 cm, contiguous); (d) Grade IV: Ulceration, necrosis, bleeding.
The 'SPORT trial' (A Study Evaluating Stereotactic Prostate Radiotherapy in High-Risk Localised Prostate Cancer) is the first of its kind in the UK and was a collaborative effort involving cancer researchers from Queen's University Belfast and the Belfast Health and Social Care Trust.
It identifies degree 0 (no reaction), 1 (faint erythema, dry desquamation, epilation, diminished sweating), 2 (moderate, brisk erythema, exudative dermatitis in plaques and moderate edema), 3 (exudative dermatitis, besides cutaneous folds and intense edema) and 4 (ulceration, hemorrhage, necrosis).
People having whole-brain radiation usually need 10 to 15 treatments over 2 to 3 weeks.
It identifies degree 0 (no reaction), 1 (faint erythema, dry desquamation, epilation, diminished sweating), 2 (moderate, brisk erythema, exudative dermatitis in plaques and moderate edema), 3 (exudative dermatitis, besides cutaneous folds and intense edema) and 4 (ulceration, hemorrhage, necrosis).
The first radiosurgery study, RTOG Protocol 90-05, was designed to treat patients with recurrent previously irradiated primary brain tumors and brain metastases with escalating doses of single fraction radiosurgery to establish the maximum tolerated dose.
Salvage radiation therapy to the prostate bed and pelvic lymphatic drainage combined with long-term androgen deprivation therapy is a curative treatment option for patients with node-positive prostate cancer after RP, with excellent in-field disease control.

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RTOG 0534 is a clinical trial protocol established by the Radiation Therapy Oncology Group aimed at evaluating treatment effectiveness for specific cancer patients.
Medical institutions and researchers involved in the RTOG 0534 clinical trial are required to file the protocol.
To fill out the RTOG 0534 Protocol, follow the detailed guidelines provided in the protocol document, which typically includes patient data, treatment details, and outcome assessments.
The purpose of RTOG 0534 Protocol is to collect data on the efficacy and safety of specific cancer treatments to improve patient outcomes.
Information that must be reported includes patient demographics, treatment regimens, outcomes, and any adverse events experienced during the trial.
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