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Universally Sloppy Parameter Sensitivities in Systems Biology Models
Ryan N. Gutenkunst1×, Joshua J. Waterfall2, Feral P. Casey3, Kevin S. Brown4, Christopher R. Myers5, James P. Sethna1
1 Laboratory
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What is universally sloppy parameter sensitivities?
Universally sloppy parameter sensitivities refer to the analysis of how a change in a parameter impacts the overall performance of a system or model, regardless of its industry or application.
Who is required to file universally sloppy parameter sensitivities?
The requirement to file universally sloppy parameter sensitivities depends on the specific regulations or guidelines set by the governing body or organization overseeing the particular system or model. In some cases, it may be mandatory for all parties involved, while in others, it may only apply to certain stakeholders or entities.
How to fill out universally sloppy parameter sensitivities?
The process of filling out universally sloppy parameter sensitivities will vary depending on the specific requirements and guidelines. Generally, it involves identifying the parameters of the system or model, conducting sensitivity analyses to assess their impact on the overall performance, and documenting the findings.
What is the purpose of universally sloppy parameter sensitivities?
The purpose of universally sloppy parameter sensitivities is to gain a better understanding of how changes in individual parameters can affect the overall performance and outcomes of a system or model. It helps to identify and assess the sensitivity of different variables, enabling more informed decision-making and risk management.
What information must be reported on universally sloppy parameter sensitivities?
The specific information that must be reported on universally sloppy parameter sensitivities will depend on the regulations, guidelines, or standards set by the governing body or organization. Generally, it may include the identified parameters, the sensitivity analysis methodology used, the results of the analysis, and any recommended actions based on the findings.
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