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CONFIDENTIAL The following contains confidential, proprietary information which is the property of Mati TherapeuticsPROTOCOL: CLINICAL STUDY TGLA202101A 90Day, OpenLabel, MultiSite, Pilot Study Evaluating

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Determine the variables or factors that you want to test in the experiment.

02

Randomly assign the participants into two groups.

03

Implement the treatment or intervention to one group while the other group serves as the control.

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After a set period of time, switch the treatment or intervention between the two groups.

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Collect data on the outcomes of interest for both groups.

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Analyze the results to see if there are any differences between the two groups.

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Scientists conducting clinical trials to test the impact of a new drug or therapy.

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What is a randomized crossover open?

A randomized crossover open is a type of clinical trial design where participants are randomly assigned to different treatment groups and then switch to another group at a certain point during the study.

Who is required to file a randomized crossover open?

Researchers and investigators conducting clinical trials are required to file a randomized crossover open.

How to fill out a randomized crossover open?

To fill out a randomized crossover open, researchers must provide detailed information about the study design, participant eligibility criteria, treatment interventions, and outcome measures.

What is the purpose of a randomized crossover open?

The purpose of a randomized crossover open is to compare the efficacy and safety of different treatments or interventions in a controlled setting.

What information must be reported on a randomized crossover open?

Researchers must report information such as study protocols, participant demographics, treatment allocation methods, adverse events, and study outcomes.

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