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Molecules
ArticleBulged and Canonical Quadruple Conformations
Determine NDK Binding Specificity
Mikhail Pylon 1,2, Trivia M. Jackson 1 and M. Elizabeth Troupe 1, *
1
2×Department of Biological Science
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How to fill out bulged and canonical g-quadruplex
How to fill out bulged and canonical g-quadruplex
01
To fill out a bulged G-quadruplex, follow these steps:
02
Identify the bulged nucleotides in the G-quadruplex sequence. These are the nucleotides that deviate from a standard G-quartet structure.
03
Assign the appropriate hydrogen bonding patterns to the bulged nucleotides. These patterns should be consistent with the neighboring nucleotides in the G-quadruplex structure.
04
Determine the relative orientation and stacking interactions of the bulged nucleotides with the surrounding G-quartets.
05
Adjust the loop lengths and connecting nucleotides as needed to maintain the overall stability of the G-quadruplex structure.
06
07
To fill out a canonical G-quadruplex, follow these steps:
08
Identify the G-quartets in the G-quadruplex sequence. These are the sets of four consecutive guanine nucleotides with hydrogen bonding patterns.
09
Assign the appropriate hydrogen bonding patterns to each G-quartet.
10
Determine the relative orientation and stacking interactions of the G-quartets within the G-quadruplex structure.
11
Adjust the loop lengths and connecting nucleotides as needed to maintain the overall stability of the G-quadruplex structure.
Who needs bulged and canonical g-quadruplex?
01
Bulged and canonical G-quadruplex structures are studied and of interest to various scientific disciplines and fields, including:
02
- Structural biology and biophysics researchers studying nucleic acid structures and interactions
03
- Chemists and drug discovery scientists developing G-quadruplex-targeting therapeutics
04
- Genomic researchers investigating the role of G-quadruplex structures in gene regulation and genome stability
05
- Cancer biologists exploring the potential of G-quadruplexes as cancer biomarkers and therapeutic targets
06
- Nanotechnology researchers utilizing G-quadruplexes for the design of functional materials and devices
07
- Computer scientists and bioinformaticians analyzing and predicting G-quadruplex structures in genomic data
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What is bulged and canonical g-quadruplex?
Bulged g-quadruplexes are structures formed by guanine-rich nucleic acid sequences that contain additional unpaired nucleotides, creating a 'bulge' in the typical square planar arrangement of guanine quartets seen in canonical g-quadruplexes.
Who is required to file bulged and canonical g-quadruplex?
Individuals or entities dealing with the relevant scientific research or applications involving g-quadruplex structures, such as geneticists and molecular biologists, may be required to file documents pertaining to bulged and canonical g-quadruplex.
How to fill out bulged and canonical g-quadruplex?
Filing bulged and canonical g-quadruplex typically involves providing detailed information on the specific structure, sequence, and relevant experimental data concerning the g-quadruplex in question.
What is the purpose of bulged and canonical g-quadruplex?
The purpose of studying bulged and canonical g-quadruplexes is to understand their biological functions, roles in gene regulation, and potential applications in therapeutic development.
What information must be reported on bulged and canonical g-quadruplex?
Required information often includes the sequence of the g-quadruplex, structural features, experimental observations, and implications for biological processes.
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