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1 Quarter of FY 23 Summary of eMERGE/PRIMED Joint Meeting: February 2nd, 2023 Zoom & InPersonTime Event 8:308:50 AMNHGRI Program Introduction | Iman Martin (NHGRI, PRIMED) & Robb Rowley (NHGRI, eMERGE)8:509:20
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How to fill out a multi-ancestry polygenic risk

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How to fill out a multi-ancestry polygenic risk

01
Gather the necessary genetic data from individuals with diverse ancestry.
02
Use a genotyping or sequencing method to identify and analyze genetic variations in the DNA of these individuals.
03
Perform quality control measures to ensure the accuracy and reliability of the genetic data.
04
Apply statistical techniques to identify genetic variants that are associated with specific traits or conditions.
05
Combine the genetic variants from multiple ancestries to create a multi-ancestry polygenic risk score.
06
Interpret the polygenic risk score by comparing it to a reference population or using established thresholds.
07
Provide appropriate counseling and guidance based on the individual's polygenic risk score.

Who needs a multi-ancestry polygenic risk?

01
Researchers studying the genetic basis of complex traits or diseases.
02
Healthcare providers looking to assess an individual's risk for certain conditions based on their genetic profile.
03
Individuals who are interested in understanding their genetic predisposition to certain traits or diseases.

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A multi-ancestry polygenic risk is a measure that combines genetic information from multiple ancestral backgrounds to assess the likelihood of an individual developing certain traits or conditions, such as diseases.
Individuals who undergo genetic testing and wish to report their polygenic risk scores based on multiple ancestries are typically required to file a multi-ancestry polygenic risk.
To fill out a multi-ancestry polygenic risk, individuals should collect their genetic testing results, complete any required forms provided by relevant health authorities or genetic counseling services, and submit the information as instructed.
The purpose of a multi-ancestry polygenic risk is to provide a more comprehensive understanding of genetic predispositions across diverse populations, aiding in personalized medicine and targeted prevention strategies.
Information that must be reported includes the individual's genetic risk scores, ancestral background data, and any relevant health information or family history that may impact health risk assessments.
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