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This acknowledgement is intended to:1) Clarify terms of the SMART IRB Agreement that were intentionally designed to be flexible to accommodate the needs of Reviewing IRBs and Relying Institutions
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Who needs smart-irb-acceptance-and-flexibility-agreement?

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Researchers conducting studies that involve multiple institutions or organizations.
02
Institutional Review Boards (IRBs) responsible for overseeing research involving human subjects.

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The smart IRB acceptance and flexibility agreement is a formal agreement that allows institutions to rely on a central Institutional Review Board (IRB) for the review of research protocols, facilitating multi-site research.
Research institutions that intend to participate in multi-site studies and wish to use a central IRB for ethical review must file the smart IRB acceptance and flexibility agreement.
To fill out the smart IRB acceptance and flexibility agreement, institutions need to provide their institutional information, designate a signatory official, and outline their participation in the agreement, paying special attention to compliance obligations.
The purpose of the smart IRB acceptance and flexibility agreement is to streamline the IRB review process for multi-site research studies, reduce duplication of efforts, and enhance collaboration among research institutions.
Institutions must report their institutional details, the type of research they intend to conduct, the associated investigators, and any specific compliance requirements or agreements relevant to their participation.
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