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MICHIGAN DEPARTMENT OF ENVIRONMENTAL QUALITY ___ INTEROFFICE COMMUNICATION ___ February 3, 2017TO:Dimethylacetamide File (CAS No. 127195)FROM:Mike HEPA, Air Quality Division, Toxics UnitSUBJECT:Derivation
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How to fill out toxic screening level justification

01
Determine the specific toxic substances that need to be screened for.
02
Collect relevant data on the toxicity of the substances, including toxicity values and exposure parameters.
03
Conduct a risk assessment to determine if the substances pose a potential risk to human health or the environment.
04
Justify the selection of specific toxic screening levels based on the risk assessment findings.
05
Document the justification process and the rationale for the chosen toxic screening levels.

Who needs toxic screening level justification?

01
Environmental regulators
02
Health and safety professionals
03
Companies handling or producing toxic substances
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Toxic screening level justification is a documentation process that provides a rationale for the selection of specific chemical thresholds when assessing potential toxicity levels of substances used or produced by an organization.
Businesses and organizations that handle chemicals above certain thresholds, typically those subject to environmental regulations, are required to file toxic screening level justification.
To fill out toxic screening level justification, organizations must provide information on the chemicals used, explain the rationale for chosen screening levels, and ensure all relevant data complies with regulatory requirements.
The purpose of toxic screening level justification is to ensure that the selection of toxicity thresholds is based on sound scientific evidence and regulatory standards, thereby protecting public health and the environment.
The report must include information about the specific chemicals, their corresponding toxicity levels, the methodology used for determination, and any supporting data that justifies the screening levels chosen.
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