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Study Design. 7, No. 3 / Juliet 2021 /p. 2934/ PPR JournalNeuromodulatory effects of Transcranial Pulsed Current Stimulation (PCs) in Fibromyalgia: protocol for a double blinded, sham controlled, randomized
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How to fill out a randomized double-blind sham-controlled

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How to fill out a randomized double-blind sham-controlled

01
Obtain the necessary approvals for conducting the study from relevant ethics committees or regulatory bodies.
02
Randomly assign participants into different groups to ensure unbiased allocation.
03
Use a double-blind approach where neither the participants nor the researchers know who is receiving the actual treatment.
04
Use a sham treatment as a control to mimic the actual treatment but without any therapeutic effect.
05
Monitor and record the outcomes of each group while keeping the treatment assignments confidential.
06
Analyze the results to determine the efficacy of the actual treatment compared to the sham treatment.

Who needs a randomized double-blind sham-controlled?

01
Individuals or organizations conducting clinical trials or research studies that aim to evaluate the effectiveness of a new treatment or intervention.
02
Researchers looking to minimize bias and increase the validity of their study findings.
03
Regulatory agencies or health authorities requiring a rigorous study design for the approval of new treatments.
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A randomized double-blind sham-controlled study is a type of clinical trial design where participants are randomly assigned to either the treatment group or a control group that receives a sham or placebo intervention. Neither the participants nor the researchers know who is in which group, minimizing bias and allowing for an objective evaluation of the treatment's efficacy.
Researchers or organizations conducting clinical trials that involve testing a new treatment or intervention typically are required to file reports of randomized double-blind sham-controlled studies. This may include pharmaceutical companies, academic institutions, or individual researchers.
Filling out a randomized double-blind sham-controlled encompasses documenting the study design, including participant recruitment, randomization process, intervention details, outcomes measured, and statistical analysis planned. It requires a thorough protocol that outlines these elements before the trial begins.
The purpose of a randomized double-blind sham-controlled study is to eliminate bias, minimize placebo effects, and determine the true efficacy and safety of a treatment. This design helps to ensure that the results are reliable and can be generalized to a broader population.
Information that must be reported includes the study hypothesis, methodology, participant demographics, intervention specifics, outcome measures, randomization method, blinding techniques, statistical analysis plans, and results including both positive and negative findings.
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