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BeiGe ne, Ltd. BGB900101 Protocol Amendment 1.0CONFIDENTIAL 12 June 2018CLINICAL STUDY PROTOCOL Title:Phase 12 Study Investigating Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor

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History of changes can be filled out by documenting the date, nature of change, reason for change, and person responsible for the change.

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The purpose of history of changes is to track and record all modifications made over time for accountability and traceability purposes.

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