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PEARLAdjusting for unmeasured confounding in nonrandomized longitudinal studies: a methodological review Street er, AJ; Lin, NO; Carthorse, L; Haas ova, M; Hyde, C; Member, D; Henley, WE Published
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01
Identify potential confounders that were not measured in the study.
02
Use sensitivity analysis to estimate the magnitude of potential bias due to unmeasured confounding.
03
Apply statistical methods such as propensity score matching or instrumental variable analysis to adjust for unmeasured confounding.
04
Interpret the results cautiously, taking into account the possibility of residual confounding.

Who needs adjusting for unmeasured confounding?

01
Researchers conducting observational studies where randomization is not possible.
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Policy makers who rely on observational data to make decisions.
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Anyone analyzing data where unmeasured confounding may be a threat to internal validity.
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Adjusting for unmeasured confounding involves accounting for variables that were not measured or included in the analysis, in order to more accurately assess the relationship between the exposure and the outcome.
Researchers conducting studies or analyses where unmeasured confounding may be present are required to consider and report on adjusting for it.
Adjusting for unmeasured confounding can be done using statistical techniques such as sensitivity analysis or propensity score matching.
The purpose of adjusting for unmeasured confounding is to reduce bias and improve the validity of study findings.
Researchers must report the methods used to adjust for unmeasured confounding, as well as any assumptions made in the analysis.
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