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Boris preprint DOI: https://doi.org/10.1101/2024.01.15.575653; this version posted January 15, 2024. The copyright holder for this preprint (which was not certified by peer review) is the author/funder,
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01
Translation initiation:
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The process starts with the binding of the small ribosomal subunit to the mRNA.
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The initiator tRNA molecule carrying methionine binds to the start codon on the mRNA.
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The large ribosomal subunit then joins the complex, forming the full ribosome.
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Translation elongation:
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The ribosome moves along the mRNA, reading the codons and bringing in tRNA molecules with complementary anticodons.
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Peptide bonds are formed between the amino acids carried by the tRNA molecules, creating a growing polypeptide chain.
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The ribosome continues this process until it reaches a stop codon, at which point translation termination occurs.

Who needs translation initiation or elongation?

01
Translation initiation and elongation are essential processes for all living organisms that need to synthesize proteins.
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These processes are required for gene expression and protein synthesis, which are fundamental for cell growth, development, and function.
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Translation initiation refers to the process by which the ribosome assembles around the mRNA and the first tRNA, starting protein synthesis. Elongation is the subsequent stage where amino acids are added to the growing polypeptide chain as the ribosome moves along the mRNA.
Entities involved in biotechnology, pharmaceuticals, or other research and development sectors that require regulatory compliance for translation initiation or elongation need to file these reports.
To fill out translation initiation or elongation, gather necessary data such as project details, involved parties, and regulatory information, then complete the specified forms provided by the overseeing regulatory body.
The purpose of translation initiation or elongation is to ensure proper documentation and compliance with regulatory guidelines in research or product development processes, safeguarding intellectual property and maintaining standards.
Information that must be reported includes the nature of the translation process, the entities involved, project timelines, and data supporting the methodology used in the translation process.
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