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pharmaceutics ReviewMicroneedleMediated Transdermal Delivery of Genetic Materials, Stem Cells, and Secretome: An Update and Progression Avelia Devina Calista Nainggolan 1 , Qonita Kurnia Anjani 2
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01
Clean the area of skin where the microneedles will be applied.
02
Prepare the microneedle device according to the manufacturer's instructions.
03
Apply the microneedle device to the skin, applying gentle pressure to ensure proper penetration.
04
Once the microneedles are in place, apply the drug formulation to the area to facilitate delivery.
05
Leave the device on for the recommended amount of time, allowing the drug to be absorbed through the skin.
06
Remove the device carefully to avoid damaging the skin.
07
Clean the area again and monitor for any adverse reactions.

Who needs microneedle-mediated transdermal delivery of?

01
Individuals who require medication but have difficulty with traditional injections.
02
Patients needing rapid drug delivery and absorption, such as for vaccines or pain relief.
03
People with chronic skin conditions that require localized treatment.
04
Those looking for a less painful alternative to hypodermic needles.
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Microneedle-mediated transdermal delivery is a method that uses small needles to penetrate the outer layer of the skin, allowing for the delivery of drugs or vaccines directly into the dermis or systemic circulation.
Typically, manufacturers or developers of microneedle-based drug delivery systems are required to file for regulatory approval or compliance documentation.
Filling out the microneedle-mediated transdermal delivery documentation generally involves providing detailed information about the product formulation, clinical data, manufacturing processes, and safety evaluations.
The purpose of microneedle-mediated transdermal delivery is to enhance drug absorption, improve patient compliance, reduce pain associated with conventional injection methods, and enable the delivery of a wider range of therapeutic agents.
Key information that must be reported includes product specifications, preclinical and clinical trial results, manufacturing processes, stability data, and safety assessments.
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