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TECHNOLOGICAL INNOVATION AND RESOURCESQuantifying Positional Isomers (QPI) by TopDown Mass Spectrometry Authors Andrea M. Brunner, Philip Lssl, Paul P. Geurink, Huib Ovaa, P. Albanese, A. F. Maarten
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01
Identify the compound and its molecular formula.
02
Determine all possible positional isomers based on the functional groups present.
03
Draw each isomer, ensuring correct connectivity and structure.
04
Assign numbers to the carbon atoms for each isomer.
05
Count the distinct positional isomers and list them.
06
Fill out the quantifying positional isomers template with necessary information for each isomer, such as name, position, and structure.

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Chemists working on organic synthesis.
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Students studying organic chemistry.
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Quantifying positional isomers (QPI) refers to the process of identifying and enumerating different isomers of a chemical compound that differ in the arrangement of atoms or groups across positions in its molecular structure.
Entities involved in the production, importation, or manufacturing of chemical compounds that have positional isomers are typically required to file a QPI.
To fill out the QPI, individuals need to provide details about the chemical compounds, their respective isomers, and any associated structural diagrams or formulas illustrating the positions of atoms/groups in the molecules.
The purpose of the QPI is to ensure proper documentation and regulation of chemical substances, facilitating safety assessments and compliance with chemical safety standards.
The report should include the chemical name, CAS number, detailed descriptions of each positional isomer, and data regarding their physical and chemical properties.
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