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Edinburgh Research Explorer Factors associated with attendee adherence to COVID19 guidance during the 2021 DCMS Events Research Programme Phase 1 (Final report)Citation for published version: Templeton,

How to fill out a self-controlled case series

How to fill out a self-controlled case series

1. Define the study population and identify the cases that will be included in the analysis.
2. Collect relevant data on the exposure of interest, ensuring it is measured consistently across all cases.
3. Determine the time periods of risk and non-risk for the exposure to analyze the association between exposure and outcome.
4. Use logistic regression or other statistical methods to assess the risk of outcome during exposure period versus non-exposure period.
5. Adjust for potential confounding variables to obtain more accurate results.
6. Interpret the results, discussing any potential biases and limitations of the study.

Who needs a self-controlled case series?

1. Researchers studying the effects of transient exposures on the health outcomes of individuals.
2. Epidemiologists looking to understand the dynamics of disease occurrence.
3. Public health officials evaluating the safety of vaccines or medications.
4. Clinicians interested in the relationship between specific exposures and patient outcomes.

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What is a self-controlled case series?

A self-controlled case series is a statistical method used to analyze the occurrence of events in individuals over time, allowing each individual to serve as their own control. It is often employed in epidemiology to evaluate the effects of vaccinations or other treatments by comparing event rates during different time periods.

Who is required to file a self-controlled case series?

Typically, researchers or epidemiologists involved in studying the safety and effectiveness of medical interventions, such as vaccines, may be required to file a self-controlled case series.

How to fill out a self-controlled case series?

To fill out a self-controlled case series, researchers must gather data on the events of interest and define the exposure periods and risk periods. They then apply appropriate statistical models to analyze the data, taking care to clearly document the methodology and findings.

What is the purpose of a self-controlled case series?

The purpose of a self-controlled case series is to estimate the incidence of an outcome in relation to a specific exposure while controlling for confounders by comparing the same individuals across different time periods.

What information must be reported on a self-controlled case series?

Information that must be reported includes study design, population characteristics, event definitions, exposure timing, statistical methods used, and results including incidence rates and confidence intervals.