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This document outlines the protocol for a Phase 1 clinical trial evaluating the safety and efficacy of AZD1775 (MK-1775), a selective Wee1 kinase inhibitor, administered concurrently with radiation therapy in pediatric patients diagnosed with diffuse intrinsic pontine gliomas (DIPG). The trial aims to estimate the maximum tolerated dose (MTD) of AZD1775 and assess its toxicity profile, as well as to preliminarily define its antitumor activity.
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What is advl1217?
ADVL1217 is a form used by certain tax-exempt organizations to report on their activities and ensure compliance with IRS regulations.
Who is required to file advl1217?
Tax-exempt organizations that meet specific criteria, such as those with annual gross receipts over a certain threshold or those that engage in certain types of activities, are required to file ADV1217.
How to fill out advl1217?
To fill out ADV1217, organizations should gather necessary financial and operational information, complete the form accurately, and follow the instructions provided by the IRS to ensure that all required fields are filled.
What is the purpose of advl1217?
The purpose of ADV1217 is to provide transparency regarding the operations and financial activities of tax-exempt organizations to the IRS and the public.
What information must be reported on advl1217?
Organizations must report information including income, expenses, activities, and any changes in governance or operational structure on ADV1217.
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