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Original Article Influence of Insertion/Deletion Polymorphism of the Angiotensin Converting Enzyme Gene on Adiposity and Cardiac Function in Patients with Heart Failure Marla Darlene Machado Vale,1,2
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01
Identify the specific insertion or deletion polymorphism you are investigating.
02
Gather relevant samples or data that contain the genetic sequences of interest.
03
Use bioinformatics tools to align the sequences and locate the insertion/deletion regions.
04
Analyze the variant's impact on gene function, phenotype, or disease association.
05
Document your findings with clear annotations on the significance of the polymorphism.

Who needs influence of insertiondeletion polymorphism?

01
Genetic researchers studying the role of polymorphisms in health and disease.
02
Medical professionals looking to understand genetic factors in patient diagnoses.
03
Pharmacogenomics experts analyzing drug response related to genetic variations.
04
Biologists investigating evolutionary processes involving genomic changes.
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Insertion-deletion polymorphism refers to variations in a DNA sequence where sections of DNA are inserted or deleted. This can influence gene function and contribute to genetic diversity, disease susceptibility, and phenotypic variation in a population.
Researchers conducting genetic studies or clinical trials that examine the effects of genetic variations, including insertion-deletion polymorphisms, are typically required to file related information with regulatory bodies, especially if the findings impact public health or safety.
Filing requires detailed documentation of the polymorphism, including its genetic location, associated phenotypes, methods used to identify the variation, and implications for health or research. Specific forms and procedures may vary by regulatory body.
The purpose is to understand the biological significance of these genetic variations, their impact on human health, susceptibility to diseases, and their potential role in personalized medicine.
Information that typically needs to be reported includes the genetic sequence changes, associated phenotypes, methodologies for detection, implications for genetic disorders, and any relevant clinical or epidemiological findings.
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