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t fUNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549FORM 10K (Mark One)ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ORTRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 00137566SYNLOGIC, INC. (Exact name of Registrant as specified in its Charter)Delaware261824804(State or

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