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What came out of that study of the results we presented here at ASCOT 2012 which is a much longer progression-free survival in the group initially randomized to reg Arafat NEM about 5 months compared to less than a month for those patients who initially were randomized to placebo you means practically is once we get this drug approved we believe it will set a new standard of care for patients who had and failed had and had that failed to control their disease and now this gives them a third option where should a drug this powerful fifth should it stay in the third line should it move earlier I think that's going to be an interesting question for clinicians and future clinical research to work on also might this drug combined with other interesting drugs that target different pathways we know that gist can be controlled sometimes very long term by shutting down the kit or PDF receptor kinases, but we're not curing these patients how can we continue to push towards cure and my trigger after nib give us a new tool to do that you, but it has certain known and expected side effects high blood pressure hand-foot syndrome some more diarrhea, so these things in our trial were highly manageable very few patients less than seven percent had to come off study because of adverse events you
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