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Want to move on and start talking about 2d NMR spectroscopy and what we're going to do we'll be using this as a tool very, very useful for structure solving there's a whole sort of alphabet soup of different techniques but rather than just unleashing a torrent I mean people do research in this area just like they do research in organic chemistry and so a big thing is invented a new technique to solve specialized problems but rather than trying to sort of talk broadly about everything we're gonna focus on getting a few tools in our toolbox and see how to use these techniques to address different problems we'll start out with two tools in the toolbox that will be HMC and cosy techniques and then we'll add some more tools, and I'll try to try to put them into some some sort of context there are two additional lectures that aren't specifically on 2d that will come in either possibly next time or the time after that, so we'll be talking specifically about the nuclear overhauled effect which applies to 1d NMR as well and we'll be talking about dynamic NMR and dynamic effects in NMR spectroscopy, but we're going to start so our next homework set will start to bring in 2d, and I'd like to to get you familiar with the tools alright theory I'm gonna start really, really simple-minded and I think this is actually a good way to think about things so in one day we said the basic idea was you pulse, and then you observe right that's your 90-degree pulse to observe is your f ID have you now seen your F ID on the spectrometers have you seen this you know the little Wiggly squiggly cosine wave with a die off, so this is your F ID and of course what you've got here is an amplitude domain and then over here you have time right this is literally your signal dying with time in the cosine wave that corresponds to the periodicity of the various nuclei and so the whole idea in a 1d Fourier transform is this time domain on the x-axis ends up getting transformed to a frequency domain and that's your parts per million and so your spectrum still has amplitude on the vertical axis, and it has frequency in the units of ppm on the horizontal dimension and the reason we call this one-dimensional NMR spectroscopy is not because this is a 1d graph it's not you'd say this is a 2d graph it's because you have one time dimension and that gets transformed to a frequency dimension now in 2d NMR you get two time domains two time dimensions in the F ID, and they get transformed into two frequency domains, so I'm gonna give you just as I have given you my simplified version of an NMR spectrometer of an NMR spectrometer an IR spectrophotometer and a mass spectrometer and so forth I'll give you my simplified version of a 2d pulse sequence a 2d pulse a sequence is going to be pulse weight pulse observe and so what you do when you do this is you get two time dimensions because the weight is you're waiting for some time you're going to vary the weight, and then you observe and so this first...
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