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This document outlines a public health response plan for managing cephalosporin-resistant Neisseria gonorrhoeae, focusing on surveillance, treatment guidelines, and public health interventions to
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How to fill out CEPHALOSPORIN-RESISTANT NEISSERIA GONORRHOEAE PUBLIC HEALTH RESPONSE PLAN

01
Gather relevant epidemiological data on cephalosporin-resistant Neisseria gonorrhoeae cases in your area.
02
Assemble a multidisciplinary response team including public health officials, healthcare providers, and epidemiologists.
03
Develop a communication plan to disseminate information to healthcare providers and the public regarding the threat of cephalosporin-resistant Neisseria gonorrhoeae.
04
Establish testing protocols to identify and confirm cases of cephalosporin-resistant Neisseria gonorrhoeae.
05
Create guidelines for treatment options and alternative therapies for affected individuals.
06
Promote sexual health education and safe practices in the community.
07
Implement surveillance systems to monitor cases and assess the effectiveness of the response plan.
08
Review and revise the response plan based on ongoing data and feedback from stakeholders.

Who needs CEPHALOSPORIN-RESISTANT NEISSERIA GONORRHOEAE PUBLIC HEALTH RESPONSE PLAN?

01
Public health officials responsible for managing infectious disease outbreaks.
02
Healthcare providers who treat patients with gonorrhea.
03
Epidemiologists monitoring trends in antibiotic resistance.
04
Community health organizations focused on sexual health education.
05
Government agencies involved in public health policy.
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If that initial injection of ceftriaxone doesn't beat the bacteria, a doctor should prescribe a higher dose, potentially with another “second-line” antibiotic, Dr. Russo says. “This is why culture and susceptibility testing is important,” he explains. “It may identify alternatives.”
In one clinical trial, dual treatment with single doses of IM gentamicin 240 mg plus oral azithromycin 2 g cured 100% of cases (lower one-sided 95% CI bound: 98.5%) and can be considered an alternative to ceftriaxone for persons with cephalosporin allergy (885).
Due to emerging strains of drug-resistant Neisseria gonorrhoeae, the bacterium that causes gonorrhea, the Centers for Disease Control and Prevention recommends that uncomplicated gonorrhea be treated with the antibiotic ceftriaxone. This antibiotic is given as a shot, also called an injection.
At present, the only CDC-recommended treatment of uncomplicated urogenital, anorectal, and pharyngeal gonorrhea is monotherapy with a single intramuscular dose of ceftriaxone 500 mg. If the recommended injectable treatment is not possible, then EPT via a single dose of 800mg cefixime should be considered.
Cephalosporin-resistant Neisseria gonorrhoeae is a major public health concern. N. gonorrhoeae of multiantigen sequence type G1407 and multilocus sequence type 1901 is an internationally spreading cephalosporin-resistant clone.
Test the patient's sex partners from the two months preceding the patient's initial gonorrhea diagnosis date (preferably with culture from all exposed sites) and empirically treat these partners with ceftriaxone 250 mg intramuscularly and azithromycin 1 gram orally as dual therapy.

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The CEPHALOSPORIN-RESISTANT NEISSERIA GONORRHOEAE PUBLIC HEALTH RESPONSE PLAN is a strategic framework designed to address the emergence and spread of Neisseria gonorrhoeae strains that are resistant to cephalosporin antibiotics. It outlines actions to detect, manage, and control these resistant strains in the community to prevent further transmission and ensure effective treatment.
Healthcare providers, laboratories, and public health officials who identify cases of cephalosporin-resistant Neisseria gonorrhoeae are required to file the response plan. This includes clinicians diagnosing gonorrhea, laboratories reporting resistant strains, and public health agencies coordinating the response.
To fill out the CEPHALOSPORIN-RESISTANT NEISSERIA GONORRHOEAE PUBLIC HEALTH RESPONSE PLAN, the responsible entity should provide detailed information on the identified cases, including patient demographics, clinical details, laboratory results, and any treatment administered. Additionally, it may require outlining public health actions taken or planned in response to the cases.
The purpose of the CEPHALOSPORIN-RESISTANT NEISSERIA GONORRHOEAE PUBLIC HEALTH RESPONSE PLAN is to mitigate the public health impact of cephalosporin-resistant gonorrhea. It aims to ensure timely reporting, coordinated response efforts, and implementation of effective control measures to reduce transmission and protect public health.
The information required to be reported includes patient identifiers, infection details, laboratory confirmation of cephalosporin resistance, treatment provided, and any related risk factors. Additionally, it may also involve public health interventions undertaken to manage and contain the outbreak.
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