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Regulations governing the registration of depositary shares, securities of Canadian issuers offered for cash, and securities to be issued in exchange offers or business combinations under the Securities
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The CFR is divided into 50 titles that represent broad areas subject to Federal regulation. Each title is divided into chapters, which usually bear the name of the issuing agency. Each chapter is further subdivided into parts that cover specific regulatory areas.
The regulations found at 45 CFR part 46 are based in large part on the Belmont Report and were written to offer basic protections to human subjects involved in both biomedical and behavioral research conducted or supported by HHS.
Specifically, 21 CFR Part 11 sets forth the criteria to ensure the trustworthiness, security, and reliability of systems and processes related to electronic records and signatures.
The HHS regulations require that an investigator obtain legally effective informed consent from subjects or a legally authorized representative before the subjects may be involved in research (45 CFR 46.116), unless this requirement has been waived by an IRB.
HHS regulations at 45 CFR 46.116 state that no investigator may involve a human being as a subject unless the investigator has obtained the legally effective informed consent of the subject or the subject's legally authorized representative.
(a) This part applies to all clinical investigations regulated by the Food and Drug Administration under sections 505(i) and 520(g) of the Federal Food, Drug, and Cosmetic Act, as well as clinical investigations that support applications for research or marketing permits for products regulated by the Food and Drug

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CFR Section 239 refers to specific regulations within the Code of Federal Regulations that govern the filing of Form S-1, which is used for registration under the Securities Act of 1933.
Entities that are looking to register securities for public sale in the United States must file CFR Section 239, typically including corporations and other issuers.
To fill out CFR Section 239, an issuer must complete the necessary registration statement, including detailed disclosures about the company, its finances, and the offering. This typically involves using the Form S-1 and following the guidelines provided by the SEC.
The purpose of CFR Section 239 is to ensure transparency and provide potential investors with essential information about the securities being offered, helping them make informed investment decisions.
CFR Section 239 requires reporting of information such as the issuer's financial statements, business operations, risk factors, management structure, and details regarding the securities being offered.
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