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BMJ 2014;348:g1458 DOI: 10.1136/bmj.g1458 (Published 4 March 2014)Page 1 of 10ResearchEffectiveness of quadrivalent human papillomavirus vaccine for the prevention of cervical abnormalities: case

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Identify the research question and determine the variables of interest.

02

Select cases (individuals with the outcome of interest) and controls (individuals without the outcome of interest) for the study.

03

Match cases and controls on potential confounding variables if possible.

04

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05

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What is case-control study nested within?

Case-control study is nested within observational research designs.

Who is required to file case-control study nested within?

Researchers conducting case-control studies are required to file.

How to fill out case-control study nested within?

Case-control study can be filled out by collecting data on cases and controls and analyzing the association between exposure and outcome.

What is the purpose of case-control study nested within?

The purpose of case-control study is to investigate the relationship between exposures and outcomes in a retrospective manner.

What information must be reported on case-control study nested within?

Information on selection criteria, exposure assessment, outcome assessment, and statistical analysis must be reported on case-control study.

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