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MICHIGAN DEPARTMENT OF ENVIRONMENT, GREAT LAKES, AND ENERGY ___ INTEROFFICE COMMUNICATION ___ September 17, 2019TO:File for Nickel (CAS No. 7440020) Nickel Sulfate (CAS No. 7786814) Nickel Oxide (CAS
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How to fill out toxic screening level justification

01
To fill out toxic screening level justification, follow these steps:
02
Gather relevant information on the toxic substance for which you need to establish a screening level.
03
Identify the target population or environmental receptors for the screening level calculation.
04
Determine the exposure route(s) for the toxic substance, such as inhalation, ingestion, or dermal contact.
05
Collect data on exposure factors, including duration of exposure, frequency of exposure, and exposure pathways.
06
Calculate the screening level by considering toxicological reference values, such as acceptable daily intake (ADI) or reference dose (RfD), and adjusting for exposure factors.
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Justify the selected toxicological reference value and explain any additional adjustments made based on site-specific conditions or uncertainties in available data.
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Document the entire process, including assumptions made and data sources used.
09
Review the completed toxic screening level justification for accuracy and clarity.
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Submit the toxic screening level justification to the relevant authority or entity requesting the information, if applicable.

Who needs toxic screening level justification?

01
Toxic screening level justification may be needed by various stakeholders, including:
02
- Regulatory agencies or government bodies that require information on potential human health or ecological risks of toxic substances.
03
- Environmental consultants or professionals involved in site remediation or environmental impact assessment projects.
04
- Industries or businesses handling or discharging toxic substances that need to comply with environmental regulations.
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- Researchers or scientists studying the toxicological effects of substances and their potential risks to human health or the environment.
06
- Environmental advocacy groups or organizations involved in raising awareness about the hazards of toxic substances.
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Toxic screening level justification is a formal process used to assess and document the justification for a substance's toxic level and its potential impacts on human health and the environment.
Entities such as manufacturers, importers, and distributors of chemical substances may be required to file toxic screening level justification, typically those subject to regulatory requirements around environmental and public health safety.
To fill out a toxic screening level justification, one must collect relevant data on the chemical substance, complete the specified forms with required details, and provide supporting documentation that aligns with regulatory standards.
The purpose of toxic screening level justification is to ensure that the potential risks posed by chemical substances are understood and managed, and to comply with regulatory requirements to protect public health and the environment.
Information that must be reported generally includes the name and properties of the substance, exposure data, toxicological information, risk assessment results, and any relevant safety measures taken.
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