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Boris preprint DOI: https://doi.org/10.1101/2024.05.08.593105; this version posted May 8, 2024. The copyright holder for this preprint (which was not certified by peer review) is the author/funder.

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How to fill out covalent dna-encoded library workflow

01

Prepare the DNA template by designing the sequences for the library.

02

Incorporate unique DNA barcodes into the DNA templates for identification purposes.

03

Synthesize the DNA templates using a covalent strategy to attach small molecules or compounds.

04

Encode the library by amplifying the DNA templates with PCR.

05

Screen the library by binding it to a target of interest and isolating the DNA sequences that bind.

06

Analyze the sequences to identify potential hits or leads for further investigation.

Who needs covalent dna-encoded library workflow?

01

Researchers looking to discover new small molecule compounds for drug development.

02

Scientists interested in exploring chemical diversity for different applications.

03

Pharmaceutical companies seeking to identify novel therapeutics through high-throughput screening.

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What is covalent dna-encoded library workflow?

Covalent DNA-encoded library workflow is a method used in drug discovery that utilizes DNA tags to encode chemical compounds for screening purposes.

Who is required to file covalent dna-encoded library workflow?

Researchers and pharmaceutical companies involved in drug discovery and development are required to file covalent DNA-encoded library workflow.

How to fill out covalent dna-encoded library workflow?

To fill out covalent DNA-encoded library workflow, researchers need to input information about the compounds being screened, the DNA tags used for encoding, and the screening results.

What is the purpose of covalent dna-encoded library workflow?

The purpose of covalent DNA-encoded library workflow is to streamline the drug discovery process by enabling the screening of large collections of chemical compounds in a high-throughput manner.

What information must be reported on covalent dna-encoded library workflow?

Information about the chemical compounds, DNA tags, screening methods, and screening results must be reported on covalent DNA-encoded library workflow.

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