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APPROVED BY THE YALE UNIVERSITY IRB 3/8/2022 NCT03612713HRP503B BIOMEDICAL RESEARCH PROTOCOL (20161)Protocol Title: Influence of medication on functional connectivity Principal Investigator: Sarah
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01
Identify the regions of interest (ROIs) in the brain relevant to your study.
02
Collect imaging data using techniques such as fMRI or EEG.
03
Preprocess the imaging data to correct for motion artifacts and normalize it.
04
Extract time series data from the identified ROIs.
05
Calculate functional connectivity metrics, such as correlation coefficients or coherence, between pairs of ROIs.
06
Apply statistical methods to identify significant changes in connectivity patterns.
07
Interpret the results in the context of the research question and existing literature.

Who needs altered functional connectivity to?

01
Researchers studying brain network dynamics in conditions like schizophrenia, depression, or autism.
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Clinicians aiming to understand the neural basis of cognitive or emotional disorders.
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Neuroscientists conducting basic research on brain function and connectivity.
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Pharmaceutical companies investigating the effects of drugs on brain connectivity.
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Altered functional connectivity refers to changes in the synchronous activity of different brain regions, often identified through neuroimaging techniques, that may indicate neurological or psychiatric conditions.
Researchers and clinicians conducting studies that involve neuroimaging and assessing functional connectivity are typically required to file reports on altered functional connectivity.
To fill out a report on altered functional connectivity, one must collect relevant neuroimaging data, analyze the connectivity patterns, and document findings in a standardized reporting format, ensuring all necessary information is accurately included.
The purpose of reporting altered functional connectivity is to communicate findings that may contribute to the understanding of brain function, inform clinical practices, and guide future research.
Information that must be reported includes the study design, methodology, results of the connectivity analysis, interpretations, and implications for future research or clinical application.
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