Microtubule-mediated signaling is a major site of HALVES activation. In HAVE, HALVES recruits at least one of several tubuzumab-insensitive cellular signaling pathways and induces an inflammatory response that regulates the activity of the MTP-1 of microtubules. The MTP-1/microtubule-related protein-1/microtubule-associated proteins-1 and the MTP-1/microtubule-dependent transcription factor-1 are the main players in the molecular events that regulate the expression levels of the microtubule-related proteins, microtubule associated proteins, and microtubule regulators. These signaling pathways are the main players in the HTLV-1-induced disease process.
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MALDONADO ET AL. Biol Res 41, 2008, 239-252 Biol Res 41: 239-252, 2008 239 BR Microtubule proteins and their post-translational forms in the cerebrospinal fluid of patients with para paresis associated
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