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Pro. Natl Acid. Sci. USA Vol. 80, pp. 870-873, February 1983 Medical Sciences Human hypoxanthine (guanine) phosphoribosyltransferase: An amino acid substitution in a mutant form of the enzyme isolated
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How to fill out an amino acid substitution:
01
Identify the specific amino acid substitution that needs to be filled out.
02
Determine the position of the amino acid in the protein sequence where the substitution should occur.
03
Obtain the amino acid substitution information, which could include the specific amino acid that needs to be substituted, the codon or nucleotide change, and any additional details about the substitution.
04
Fill out the amino acid substitution by accurately recording the amino acid change and any necessary information in the appropriate format or form.
Who needs an amino acid substitution:
01
Individuals with genetic disorders: Amino acid substitutions may be needed for individuals with genetic disorders that result in specific amino acid substitutions. These substitutions can affect the structure and function of proteins and may require targeted substitutions to correct or mitigate the effects of the genetic disorder.
02
Researchers studying protein structure and function: Amino acid substitutions are commonly used in research to study the impact of specific amino acid changes on protein structure, function, and interactions. Researchers may need to introduce targeted amino acid substitutions to investigate the effects on protein behavior.
03
Pharmaceutical and biotechnology industries: Amino acid substitutions are important in drug development and protein engineering. Substitutions can be used to improve the stability, activity, or specificity of a protein, making it a valuable tool for the pharmaceutical and biotechnology industries.
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What is an amino acid substitution?
An amino acid substitution refers to the replacement of one amino acid with another in a protein sequence, resulting in a change in its structure and function.
Who is required to file an amino acid substitution?
There is no specific requirement to file an amino acid substitution. It is a scientific concept studied and reported by researchers in the field of biochemistry and genetics.
How to fill out an amino acid substitution?
An amino acid substitution is not something that needs to be filled out. It is a result of genetic mutations or deliberate protein modifications that are observed and documented in research studies.
What is the purpose of an amino acid substitution?
The purpose of studying amino acid substitutions is to understand how changes in protein structure can affect protein function, which is key to understanding various genetic disorders and designing therapeutic interventions.
What information must be reported on an amino acid substitution?
When reporting an amino acid substitution, researchers typically include the specific amino acid change, the protein it occurs in, the genetic mutation responsible, and the functional consequences observed.
When is the deadline to file an amino acid substitution in 2023?
There is no specific deadline to file an amino acid substitution. It is a scientific concept that can be reported and published at any time during the year.
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