These compounds are to be evaluated for their efficacy and safety for the treatment of metastasis. In the long term, development of a novel anti-metastasis therapy might lead to the development of a combination chemotherapeutic that avoids the side effects resulting from each individual chemotherapeutic. Concerning the mechanism of action of these molecules, their in vitro activity against cancer cells and their ability to inhibit tumorigenesis in vivo are essential prerequisites for conducting clinical trials. The project aims to develop a model of tumor initiation in vivo by combining pharmacological agents with a non-invasive in vitro technique allowing the direct and non-invasive observation of the progression of metastatic tumors in vivo. Target for further investigation The main goals of this project are to develop new antiemetic in vitro that could be combined with chemotherapy agents; establish the mechanisms of action of these treatments, the efficacy of these agents as adjuvants and in vitro inhibitors of the growth of cancer cells; define the in vivo efficacy and toxicity of these compounds; determine the best doses for these compounds that are capable of increasing antitumor activity and decreasing tumor aggressiveness. The project aims to develop novel anticancer therapeutics that circumvent existing drug classes and provide better tolerability, which would reduce adverse effects and improve the safety profile of the drug. The main objectives of this project are to develop new chemotherapeutic agents that combine with anti-metastatic drugs (antibodies) during chemotherapy, by combining an antiemetic agent to facilitate the administration of an anti-metastatic agent. The use of anti-emetics as adjuvants or in adjuvant mode is planned to minimize side effects due to the use of chemotherapy and promote therapeutic effect by reducing drug side effects associated with the anti-metastatic therapy or enhancing antitumor activity of the anti-metastatic combination therapy. This project aims to establish a model of tumor initiation, including tumor promotion by enhancing or inhibiting the growth of cancer cells.
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CANCER RESEARCH 61, 2843 2846, April 1, 2001, Advances in Brief Extracellular Tumor-activated Pro drugs for the Selective Chemotherapy of Cancer: Application to and Preliminary in Vitro and in Vivo
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Extracellularly tumor-activated prodrugs are used to specifically target and treat tumor cells.
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Pharmaceutical companies or researchers developing extracellularly tumor-activated prodrugs are required to file them.
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Extracellularly tumor-activated prodrugs can be filled out by providing detailed information about the composition, synthesis, and activation mechanism of the prodrug.
What is the purpose of extracellularly tumor-activated prodrugs for?
Extracellularly tumor-activated prodrugs aim to enhance the effectiveness and specificity of cancer treatments while minimizing systemic toxicity.
What information must be reported on extracellularly tumor-activated prodrugs for?
The information that must be reported on extracellularly tumor-activated prodrugs includes the chemical structure, mode of delivery, selectivity, and efficacy against tumor cells.
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