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A Randomized Trial of Direct Mailing of Fecal Occult Blood Tests To Increase Colorectal Cancer Screening Timothy R. Church, Mark W. Hazel, Rest M. Jones, Laura K. Kosher, Gavin D. Watt, Steven J.
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Begin by clearly defining the research question or hypothesis that the randomized trial aims to address. This should be specific and relevant to the field of study.
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Design the trial protocol, including the selection criteria for participants, intervention methods, control group design, outcome measures, and data collection procedures. Ensure that the trial is ethically sound and adheres to relevant guidelines.
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Obtain ethical approvals and necessary permissions from relevant authorities or review boards before conducting the trial.
04
Recruit participants who meet the selection criteria and obtain their informed consent to participate in the trial. Randomly assign them to either the intervention group or the control group.
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Implement the intervention as per the trial protocol for the participants in the intervention group. Ensure that the control group receives a placebo or standard treatment.
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Collect data on the predetermined outcome measures at specific time points during the trial. Use appropriate statistical methods to analyze and interpret the data.
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Evaluate the results of the trial and draw conclusions based on the findings. Assess the implications of the results for future research, clinical practice, or policy-making.
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Communicate the trial findings through scientific publications, conferences, or other appropriate channels to contribute to the existing knowledge in the field.

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Researchers or scientists who aim to investigate the efficacy, effectiveness, or safety of a new intervention or treatment in a controlled and unbiased manner. Randomized trials help establish causal relationships between interventions and outcomes.
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Regulatory agencies and policymakers who require reliable evidence to assess the benefits and risks associated with new interventions or treatments before approving them for widespread use.
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Patients and public who are interested in understanding the evidence behind different treatments or interventions. Randomized trials can provide valuable information about the effectiveness and potential harms of interventions.

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