The mammalian v-SNARE (vesicular dermatitis of the respiratory epithelium) is a common and apparently innocuous inhaled pathology. We present the first evidence that the v-SNARE is a major route by which vasculo-transverse blood vessels traverse the respiratory epithelium. The v-SNARE arises when the apical and ventral surfaces of the eukaryotic pulmonary artery (EPC) migrate in a common direction. We demonstrate the presence of a v-SNARE-dependent vasculature to facilitate blood diffusion from the ER to the Golgi in the vicinity of a tumor. Thus, the v-SNARE functions to link the Golgi to the rest of the pulmonary vascular system. This mechanism serves as an interface between the vasculature surrounding the lung and vascular structures in the lung adjacent to the tumor. Implications for understanding the origin and pathogenesis of human lung disease are proposed.
Citation: Lelia Orcs, Hominin Wang, Mariella Lavazza, John T. T. Erdjument-Bromage, Xylene Amherst, and James E. Rothman Cellular Biochemistry and Biophysics Program, Molecular Biology Program, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York 10021; and Institute of Histology and Embryology, Department of Morphology, University of Geneva Medical School, 1211 Geneva 4, Switzerland; Corresponding Author: Lelia Orcs, Division of Cellular and Molecular Medicine, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. E-mail: Orcsmskcc.org.
Abstract Solute carrier-mediated transport is one of many routes in which extracellular components can enter the lungs. However, the origin and pathogenesis of human lung disease are poorly understood; this is due in part to the poor accessibility of histological and pathological specimens to researchers. We describe the formation of intracellular vasculo-transverse blood vessels (V-SNARE) by the transfer of apical and ventral extracellular components that originate from a pulmonary vascular endothelial cell to their respective pulmonary endothelial cell neighbors by diffusion.
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Published June 2, 1997 ERS-24, a Mammalian v-SNARE Implicated in Vesicle Traffic between the ER and the Golgi Inbox Park, * Lelia Orcs, Mariella Lavazza, Hedge Erdjument-Bromage, Xylene Amherst, Paul
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What is ers-24 a mammalian v-snare?
ERS-24 is a mammalian v-SNARE that is involved in vesicular trafficking, specifically in the fusion of transport vesicles with the target membrane.
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There is no specific requirement for filing ERS-24 as it is a protein involved in cellular processes and not a document that needs to be filed.
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ERS-24 is not something that can be filled out as it is a protein that exists within cells and is not a form or document.
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The purpose of ERS-24 as a mammalian v-SNARE is to mediate membrane fusion events in cellular processes, such as protein trafficking and secretion. It helps ensure that transport vesicles are properly targeted and fused with their intended destination membranes.
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There is no specific information that needs to be reported on ERS-24 as it is a protein involved in cellular processes and not a reportable document.
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ERS-24 does not have a filing deadline as it is a protein and not a document or form that needs to be filed.
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