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Available online http://arthritis-research.com/content/7/3/R485 Research article Vol 7 No 3 Open Access A web tool for finding gene candidates associated with experimentally induced arthritis in the

September 24, 2014; Accepted: June 14, 2015; Published: July 28, 2015, Copyright: © 2015 Andersson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Data Availability: The authors confirm that all data underlying the findings are fully available without restriction. All studies were conducted according to the ethical regulations of the local ethics committee (reference number: H-L-10-01). Funding: The author is not associated with any funding body in the form of a grant or salary and is funded by a private foundation. Competing interests: The authors have declared that no competing interests exist. Introduction Experimental arthritis is a well-known and severe chronic inflammatory condition associated with damage to the joints, often caused by trauma [1]–[4]. It is the most frequent cause of disability in patients with rheumatoid arthritis (RA), the most common type of arthritis in the Western world [5]. The exact etiology and pathogenesis of the disease are not fully understood and the possible prevention is an active area of research [6]. Genetic variants of the micro-RNA-125 family have been implicated in the development of experimental arthritis [7]. The gene, micro-RNA-125, is a short nucleotide repeat gene that encodes a small RNA protein (MicroRNA-125) that has been shown to produce inflammatory or degenerative responses in cells [8]. There are two forms of the MicroRNA-125 gene: a small copy (M125R) and a long copy (M125L). M125R is found primarily in the cell's nucleus, and has a major impact in the regulation of gene expression by limiting the amount of mRNA (mRNA) of various genes. M125L copies are found in membrane-associated sites, where they can facilitate protein-protein interactions between protein molecules, leading to the formation of aggregates (amino-hydrolysates or AD). The function of M125L varies widely and seems to function at an intermediate range between the regulation of gene expression and that of microRNA [9].

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